Thiago Peixoto Leal

The paper screens variants in PD-related genes in Latin American EOPD and familial PD patients, identifying pathogenic variants and contributing to the genetic characterization of these conditions in the region.

The paper identifies non-random positional overlap between common germline polymorphisms and somatic cancer mutations, suggesting intrinsically vulnerable genomic loci.

The paper characterizes the genetic landscape of Parkinson's disease in a Chilean cohort, identifying common pathogenic variants in LRRK2 and GBA1.

The paper investigates the association of MAPT haplotypes H1 and H2 with Parkinson's disease risk across diverse populations using genetic data from multiple cohorts.

NeuroPupil improves cross-species pupillometry with a deep learning framework, achieving better accuracy and efficiency while enabling reliable biological insights.

This study evaluates polygenic risk scores for Parkinson's disease in admixed Latin American populations, finding that European-derived PRS outperform ancestry-matched but underpowered datasets.

This study conducts the first XWAS in an African cohort, identifying X chromosome variants associated with Parkinson's disease susceptibility in males and females.

This study identifies Parkinson's disease susceptibility variants in a South African cohort using GWAS and local ancestry analysis, highlighting ancestry-specific genetic risk factors.

This study compares polygenic risk scores for Parkinson's disease across seven ancestries, finding varying predictive accuracy and highlighting the need for ancestry-specific models.

DeepFace improves facial tracking and cortical activity prediction in mice by building on existing tools with scalability and precision enhancements.

The paper analyzes genetic diversity in the All of Us Research Program, showing that self-identified race and ethnicity groups exhibit continuous genetic variation rather than discrete clusters, with implications for genetic association studies.

This study performs an X chromosome-wide association study (XWAS) in ASD, identifying 59 variants associated with ASD, including novel candidate genes like FGF13.

This study evaluates how imputation reference panel composition affects imputation quality in four Latin American cohorts, finding that increasing Latin American representation improves quality but results vary by population and chromosome.

The paper describes a virtual hackathon event that brought together early career scientists to develop tools for Parkinson's disease research using open science principles.

The paper conducts an X-chromosome association study in Latin American cohorts, identifying new loci linked to Parkinson Disease and replicating previous findings.

The paper identifies and replicates epistatic variant-variant interactions in Parkinson's disease across genetically diverse populations using a new pipeline called VARI3.

NATO RA prunes relatedness in genetic datasets to minimize data loss, outperforming existing methods by retaining more individuals while removing all relatives.

The paper identifies a West African-associated regulatory variant with a strong female-specific effect on BMI and fat mass in Brazilian admixed populations.

The paper analyzes African genetic contributions to the Americas, showing regional ancestry patterns and admixture dynamics linked to historical factors.