Author

Oscar J. Charles

University College LondonORCID 0000-0003-2578-5193Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Judith BreueriD· 3 shared Cristina VenturiniiD· 2 shared Richard A. GoldsteiniD· 2 shared Austen J. J. WorthiD· 1 shared Calum ForrestiD· 1 shared Charlotte A. WilliamsiD· 1 shared Claire E. AtkinsoniD· 1 shared Douglas ThorburniD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBioinformatics

Judith BreuerORCID

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3 papers

Recent·Most cited

BioinformaticsBMC BioinformaticsPeer-reviewedAug 27, 2024

HerpesDRG: a comprehensive resource for human herpesvirus antiviral drug resistance genotyping

Oscar J. Charles, Cristina Venturini, Richard A. Goldstein, Judith Breuer

HerpesDRG provides a database and tools for drug resistance mutation analysis in human herpesviruses using genotype-phenotype literature.

8 citations

humanwhole-genome sequencing

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Genetic & Genomic MedicinemedRxivPreprintSep 12, 2022

Persistent low-level variants in a subset of HCMV genes are highly predictive of poor outcome in immunocompromised patients with cytomegalovirus infection

Cristina Venturini, Julia Colston, Oscar J. Charles…·Judith Breuer

The paper identifies a viral signature from HCMV genes associated with poor outcomes in immunocompromised patients, using deep sequencing and machine learning.

2 citations

humanDNA methylation

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GeneticsbioRxivPreprintJun 4, 2021

WeightedLD: The Application of Sequence Weights to Linkage Disequilibrium

Oscar J. Charles, Joseph Roberts, Judith Breuer, Richard A. Goldstein

The paper introduces a sequence-weighting method for linkage disequilibrium calculations to reduce sampling bias by giving more weight to underrepresented sequences.

1 citation

whole-genome sequencingstatistical model

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