Cristina Venturini

The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality.

The study compares CSF and blood transcriptomes in pneumococcal meningitis patients to identify mortality-associated inflammatory responses.

Microenvironmental TGF-β is an early driver of NF1-associated tumour formation

This study identifies TGF-β as a critical microenvironmental driver of NF1-associated tumour formation and shows its inhibition can prevent tumour development.

Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses

This study compares metagenomics and targeted approaches for virus detection, finding that targeted methods improve sensitivity while untargeted ONT offers better specificity.

HerpesDRG: a comprehensive resource for human herpesvirus antiviral drug resistance genotyping

HerpesDRG provides a database and tools for drug resistance mutation analysis in human herpesviruses using genotype-phenotype literature.

Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test

The paper profiles single-cell transcriptomes and T cell receptors in human tuberculin skin tests to characterize the immune response to Mycobacterium tuberculosis.

Translating metagenomics into clinical practice of complex paediatric neurological presentations

This study demonstrates that clinical metagenomics improves diagnostic outcomes for undiagnosed complex paediatric neurological cases, particularly in immunocompromised patients.

Persistent low-level variants in a subset of HCMV genes are highly predictive of poor outcome in immunocompromised patients with cytomegalovirus infection

The paper identifies a viral signature from HCMV genes associated with poor outcomes in immunocompromised patients, using deep sequencing and machine learning.

Haplotype assignment of longitudinal viral deep-sequencing data using co-variation of variant frequencies

This paper introduces HaROLD, a method for haplotype reconstruction from longitudinal viral sequencing data using co-varying variant frequencies, showing high accuracy with synthetic datasets.

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.

Immune profiling of cord blood after prolonged rupture of membranes.

This study identifies transcriptomic changes in cord blood following prolonged rupture of membranes, suggesting immune responses to potential in utero infections.