Deeksha Thakur

The paper investigates the role of active site conformational flexibility in substrate promiscuity by comparing promiscuous and specialist enzymes using molecular dynamics simulations and tICA.

The paper introduces a framework to systematically annotate exon attributes and analyze isoform diversity by integrating protein sequences and splice site variability.

The paper presents a framework to analyze isoform diversity by integrating exonic loci and protein sequences, revealing splicing patterns in coding and non-coding regions across five organisms.