The distinct role of actin isoforms on mechanosensing-based maturation of hiPSC-derived neurons unveiled by isoform-specific mutations
Elena Battirossi, Indra Niehaus, Irene Pertici, Giada Magni, Cristiano D’Andrea, Johannes N. Greve, Massimo Reconditi, Nataliya Di Donato, Vincenzo Lombardi, Pasquale Bianco
This study investigates the role of beta- and gamma-actin isoforms in neuronal mechanotransduction using mutations linked to BWCFF syndrome, revealing distinct functional consequences.
bioRxiv · May 12, 2026 · PreprintNeuroscience