Pharmacology & ToxicologybioRxivPreprint
A metabolically resistant spexin analogue, LIT-01-144, induces potent non-opioid peripheral antinociception in persistent pain via activation of GALR2
Yann Berthomé, Glenn-Marie Le Coz, Valérie Utard…·Frédéric Simonin
This study develops a spexin analog, LIT-01-144, that activates GALR2 to provide potent non-opioid antinociception in persistent pain without central nervous system penetration.
DOI 10.64898/2026.02.19.706558