Abicumaran Uthamacumaran

This study shows that H3K27M-mutant pediatric high-grade glioma cells can be reprogrammed toward a neuronal-like state using drug combinations targeting neuronal differentiation pathways.

This paper identifies key biomarkers and pathways driving cell fate decisions in pediatric high-grade gliomas using systems medicine approaches and multi-omics data.

The paper uses network and data science techniques to analyze single-cell gene expression data from GBM and GSCs, identifying key molecular regulators and their interactions that differentiate pediatric and adult GBMs.