Cynthia Horth

This study shows that H3K27M-mutant pediatric high-grade glioma cells can be reprogrammed toward a neuronal-like state using drug combinations targeting neuronal differentiation pathways.

This study investigates the role of H3K36 methylation in epigenome integrity by analyzing knockout mouse cells, revealing its impact on enhancer activity, gene body repression, and genome compartmentalization.

This study identifies IGF2 as a therapeutic target in PRC2-deficient MPNSTs by linking PRC2 loss to chromatin remodeling and activation of the IGF2-IGF2BP axis.

The paper systematically perturbs H3K36 methyltransferases in mouse mesenchymal stem cells to reveal their distinct roles in H3K36 methylation states and genomic distribution.

This study investigates the epigenetic and transcriptomic effects of NSD1 mutations in head and neck squamous cell carcinoma, showing loss of H3K36me2 and DNA methylation, and gain of H3K27me3, leading to gene expression changes.

The paper integrates GWAS data with functional genomic annotations of decidual stromal cells to identify loci and target genes associated with gestational duration and preterm birth.