Author
Howard Hughes Medical InstituteORCID 0000-0003-2821-4505Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Lide Cha, Zedu Huang, Chandrashekhar Padhi…·Wilfred A. van der Donk
This paper identifies the final steps in fosfazinomycin biosynthesis, revealing an unexpected use of RiPP machinery to assemble phosphonate and hydrazine moieties.
Chandrashekhar Padhi, Dinh Thanh Nguyen, Lingyang Zhu…·Wilfred A. van der Donk
The P450 ApyO crosslinks a 10-residue C-terminal peptide, and substitutions in the YLY motif switch the linkage among C−C, N−C and C−O bonds.
Lide Cha, Chuyang Qian, Chandrashekhar Padhi…·Wilfred A. van der Donk
The paper identifies and characterizes a RiPP biosynthetic gene cluster that introduces nitrile groups via an AS-like enzyme, expanding knowledge of RiPP structural diversity and enzymatic versatility.