Joshua Neil Sampson

Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes

The paper introduces POLMM, a mixed model for ordinal categorical phenotypes in GWAS, showing it is computationally efficient, controls type I error, and identifies more significant variants than existing methods.

Genetic and Epigenetic Intratumor Heterogeneity Impacts Prognosis of Lung Adenocarcinoma

This study quantifies genetic and epigenetic intratumor heterogeneity in lung adenocarcinoma and links it to poor prognosis.

A Simple Approximation To The Bias Of Gene-Environment Interactions In Case/Control Studies With Silent Disease

The paper derives a theoretical approximation for bias in gene-environment interaction estimates in case-control studies with silent disease and validates it through simulations and a prostate cancer study.