Elif Fidan Acar

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

The paper identifies suppressor mutations in Mecp2-null mice that alleviate Rett syndrome symptoms by modulating DNA damage response pathways.

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.