Author

Brandon Willis

University of California, Davis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Joshua A. Wood· 3 shared K. C. Kent LloydiD· 3 shared Mary E. DickinsoniD· 3 shared Radislav SedláčekiD· 3 shared Allan BradleyiD· 2 shared Amie Creighton· 2 shared Ann‐Marie MalloniD· 2 shared Atsushi YoshikiiD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Joshua A. Wood

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse Lines

Hillary Elrick, Kevin A. Peterson, Brandon Willis, Denise Grant Lanza, Elif Fidan Acar, Edward J. Ryder, Lydia Teboul, Petr Kašpárek, Marie‐Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. M. Brown, Adam Caulder, Gemma F. Codner, , Valerie Laurin

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

Scientific Reports · Sep 30, 2024Peer-reviewedGenetics

Whole genome analysis for 163 guide RNAs in Cas9 edited mice reveals minimal off-target activity

Kevin A. Peterson, Sam Khalouei, Nour Hanafi, Joshua A. Wood, Denise Grant Lanza, Lauri G. Lintott, Brandon Willis, John R. Seavitt, Robert E. Braun, Mary E. Dickinson, Jacqueline K. White, K. C. Kent Lloyd, Jason D. Heaney, Stephen A. Murray, Arun K Ramani, Lauryl M. J. Nutter

The paper analyzes whole-genome sequencing data from Cas9-edited mice to assess off-target mutagenesis, finding minimal off-target activity across 163 guide RNAs.

Communications Biology · Jun 10, 2023Peer-reviewedGenetics

A resource of targeted mutant mouse lines for 5,061 genes

Marie‐Christine Birling, Atsushi Yoshiki, David J. Adams, Shinya Ayabe, Arthur L. Beaudet, Joanna R. BOTTOMLEY, Allan Bradley, Steve D. M. Brown, Antje Bürger, Wendy Bushell, Francesco Chiani, Hsian-Jean Genie Chin, Skevoulla Christou, Gemma F. Codner, Francesco John DeMayo, , Sandy Teichmann

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

Nature Genetics · Apr 1, 2021Peer-reviewedGenetics

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan L. Ballard, Surinder K. Batra, M.-C. Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Javier Carrillo-Salinas, Wesley Chan, Hanying Chen, , Atsushi Yoshiki

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

Genome biology · Aug 25, 2019Peer-reviewedGenetics