Molecular BiologybioRxivPreprint
Biochemical reconstitution of a major age-related cancer mutational signature by heat-induced spontaneous deamination of 5-methylcytosine residues, repair of uracil residues, and DNA replication.
The paper reconstitutes cancer mutational signature 1 by simulating spontaneous deamination of 5-methylcytosine and DNA repair processes, resulting in C>T mutations at CpG sites.
DOI 10.1101/2024.05.22.595323