Molecular BiologybioRxivPreprint
DNMT3b Dysfunction Promotes DNA cleavages at Centromeric R-loops to Increase Centromere Instability
Hsueh‐Tzu Shih, Wei‐Yi Chen, Hsin-Yen Wang…·Zee-Fen Chang
This study shows that DNMT3b dysfunction leads to centromere instability through R-loop-mediated DNA breaks and XPG/XPF cleavage.
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