BioinformaticsbioRxivPreprint
Benchmarking within-sample minority variant detection with short-read sequencing in M. tuberculosis
Shandukani Mulaudzi, Sanjana G. Kulkarni, Maximillian G. Marin, Maha R Farhat
This study benchmarks seven variant callers for detecting low-frequency variants in M. tuberculosis using simulated short-read data, finding FreeBayes performs best and introducing an error model to filter false positives.
DOI 10.64898/2026.02.13.704885