Author

Koki Makabe

Yamagata UniversityORCID 0000-0003-3168-8445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Atsushi Maejima· 1 shared Atsushi Tsugita· 1 shared Gatsogiannis Christos· 1 shared Ishin Nakahara· 1 shared Izumi Kumagai· 1 shared K. SatoiD· 1 shared Mayuka Ishii· 1 shared Misae Nazuka· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Atsushi Maejima

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1 paper

Recent·Most cited

BiochemistryCell ReportsPeer-reviewedJul 1, 2025

Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement

K. Sato, Shiro Uehara, Atsushi Tsugita…·Yoshikazu Tanaka

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

4 citations

cryo-EMexperimental assay

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