Yoshikazu Tanaka

Selective Recognition, Covalent Linkage and Chemical Exchange of Artificial Cells through Engineered α-Hemolysin

This paper engineers α-hemolysin to enable selective recognition, covalent linkage, and chemical exchange between artificial cells through a single protein system.

In-Cell Protein Crystallization via a Locally Flexible 24-mer Assembly Precursor

This study defines the assembly pathway of CipB, showing that a 24-mer precursor forms and packs into a cubic lattice, with N-terminal flexibility enabling crystallization.

Modulation of translational elongation by montanine alkaloids preferentially inhibits RNA viruses

This study identifies montanine as a potent antiviral compound that inhibits RNA viruses by targeting translational elongation and GCN1-related stress responses.

Structure-activity relationship of an all-α-helical prenyltransferase reveals a mechanism for indole prenylation.

This study determines the X-ray crystal structure of SxPT1, a prenyltransferase, and discusses its catalytic mechanism for indole prenylation.

Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

The glomerulus as a selective gate for tumor-derived extracellular vesicles in urine

This study shows the glomerulus actively transports tumor-derived extracellular vesicles into urine, revealing a mechanism for their excretion and potential use in cancer diagnostics.

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.