Author

Douglas R. Adkins

Washington University in St. LouisORCID 0000-0003-3207-8227Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ravindra UppaluriiD· 2 shared Amna Ramadan· 1 shared Andres Bur· 1 shared Ann Marie EgloffiD· 1 shared Anthony J. ApicelliiD· 1 shared Avinash RamuiD· 1 shared Benjamin M. WahleiD· 1 shared Brendan J. KnappiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

Ravindra UppaluriORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 27, 2026

High-avidity TCR signaling drives an NKG2A-positive CD8 T cell exhaustion state in human tumors

Riley D. Z. Mullins, Jesse Meir Zaretsky, Thomas F. Barrett…·Ravindra Uppaluri

This study identifies high-avidity TCR signaling via NFAT as a key driver of NKG2A-positive CD8 T cell exhaustion in human tumors, with implications for immunotherapy.

DOI 10.64898/2026.05.29.728765

humanscRNA-seq

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BioinformaticsNature CommunicationsPeer-reviewedMar 22, 2023

RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer

Kelsy C. Cotto, Yang-Yang Feng, Avinash Ramu…·Malachi Griffith

RegTools identifies splice-associated variants in cancer by integrating genomic and transcriptomic data across 9,000 tumor samples, discovering 235,778 splicing events.

131 citationstop 1%

humanwhole-genome sequencing

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