Ravindra Uppaluri

This study identifies high-avidity TCR signaling via NFAT as a key driver of NKG2A-positive CD8 T cell exhaustion in human tumors, with implications for immunotherapy.

This study shows that a cancer vaccine combined with anti-PD-1 therapy reduces tumor burden and improves survival in a head and neck cancer model with impaired T cell responses.

7-UP generates in silico 40-plex CODEX data from a 7-plex mIF panel using cellular morphology, enabling cell type classification and survival prediction across diverse samples.

RegTools identifies splice-associated variants in cancer by integrating genomic and transcriptomic data across 9,000 tumor samples, discovering 235,778 splicing events.

SPACE-GM identifies spatial motifs in cancer samples linked to recurrence and immunotherapy outcomes using geometric deep learning.

The paper designs single molecule molecular inversion probes targeting clinically relevant variants using the CIViC database, demonstrating high sensitivity and discovering missed variants in cancer samples.