Author

H. Patrick MacKnight

University of VirginiaORCID 0000-0003-3232-6155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Amy L. Lu· 2 shared Charles Edward ChalfantiD· 2 shared Xiujie XieiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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2 shared papersCancer Biology

Amy L. Lu

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 13, 2025

The long non-coding RNA, CyKILRb, augments oncogenic phenotypes via induction of PIK3R2 and activation of the PI3K/AKT axis

Xiujie Xie, H. Patrick MacKnight, Amy L. Lu, Charles Edward Chalfant

This study identifies CyKILRb as an oncogenic long non-coding RNA that promotes tumorigenesis by upregulating PIK3R2 and activating the PI3K/AKT pathway.

DOI 10.1101/2025.10.13.682173

humanstatistical model

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Molecular BiologyMolecular Therapy — Nucleic AcidsPeer-reviewedDec 5, 2024

RNA splicing variants of the novel long non-coding RNA, CyKILR, possess divergent biological functions in non-small cell lung cancer

Xiujie Xie, H. Patrick MacKnight, Amy L. Lu, Charles Edward Chalfant

The paper identifies a long non-coding RNA, CyKILR, with two splice variants that have opposing effects on tumor growth and cell survival in NSCLC.

7 citations

humanbulk RNA-seq

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