Nathan T Lawlor

This paper introduces ATAC-DoubletDetector, a read count-based method to detect multiplets in snATAC-seq data and annotate their cellular origins, achieving 85% accuracy in annotation.

BiFET improves TF footprint enrichment analysis by correcting biases in chromatin accessibility and GC content, increasing power and reducing false positives.

The paper provides multi-genomic maps of the EndoC-βH1 cell model to define gene regulatory programs in human pancreatic β cells and identifies allelic effects on cis-regulatory elements.

The paper profiles chromatin accessibility in human islets from T2D and non-diabetic individuals to identify genetic and disease-associated changes in cis-regulatory element use.