Ahrim Youn

The paper identifies the transcriptional activation of Jun and Fos genes in the AP-1 complex as a conserved aging signature in immune cells, contributing to inflammaging across mouse strains and humans.

The paper develops a statistical method to calculate the optimal number of cells needed to detect a rare subpopulation in scRNA-seq experiments, validated using dendritic cell and monocyte data.

BiFET improves TF footprint enrichment analysis by correcting biases in chromatin accessibility and GC content, increasing power and reducing false positives.

The paper profiles chromatin accessibility in human islets from T2D and non-diabetic individuals to identify genetic and disease-associated changes in cis-regulatory element use.