Author

Chimdi Walter Ndubuisi

University of MissouriORCID 0000-0003-3277-4206Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Activity by Year

2026-2026 · peak 2/yr

2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 28, 2026

Ontology-Guided Pathway Activity Identifies a Cell-Intrinsic Defense Response Program Associated with MEK Inhibitor Sensitivity

Chimdi Walter Ndubuisi

This paper introduces GOPA, a pathway activity model that identifies defense response pathways linked to MEK inhibitor sensitivity in cancer cell lines.

DOI 10.64898/2026.07.25.740732

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintJul 28, 2026

Dataset-Dependent Utility of Discrete Ricci Curvature for Transition-Region Ranking in Single-Cell Lineage Graphs

Chimdi Walter Ndubuisi

The paper evaluates the utility of discrete Ricci curvature in single-cell lineage graphs, finding it adds value in specific datasets but is not sufficient on its own.

DOI 10.64898/2026.07.25.740737

zebrafishhuman

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