GeneticsOpen BiologyPeer-reviewed
A Homology Independent Sequence Replacement Strategy in Human Cells Using a CRISPR Nuclease
Eric W. Danner, Mikhail Y. Lebedin, Kathrin de la Rosa, Ralf Kühn
This paper introduces a CRISPR-based method to replace genomic segments without homology, achieving exon replacement in 16-54% of cells.
18 citations