Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesis
Sonia Zumalave, Martín Santamarina, Nuria P. Espasandín, Daniel García‐Souto, Javier Temes, Toby M. Baker, Ana Pequeño‐Valtierra, Iago Otero, Jorge Rodríguez‐Castro, Ana Oitabén, Eva G. Álvarez, Paula Otero, Iria Díaz-Arias, Mónica Martínez‐Fernández, Peter Van Loo, , José M. C. Tubío
The paper analyzes L1 retrotransposition in tumors using long-read sequencing, revealing synchronous L1 insertions drive chromosomal crossovers early in tumorigenesis.
bioRxiv · Aug 27, 2024 · PreprintCancer Biology