Author

Manzar J. Hossain

Cold Spring Harbor LaboratoryORCID 0000-0003-3399-581XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Bruce StillmaniD· 2 shared Kuhulika BhallaiD· 1 shared Michael Tramantano· 1 shared Sanjay NaikiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

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4 top collaborators · 4 mutual co-author links

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2 shared papersMolecular Biology

Bruce StillmanORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 13, 2026

A role for CIZ1, a Nuclear Matrix Protein Overexpressed in Cancer Cells, in Controlling the Initiation of DNA Replication

Manzar J. Hossain, Michael Tramantano, Sanjay Naik, Bruce Stillman

This study identifies CIZ1 as a scaffold protein that coordinates DNA replication licensing, Cyclin-CDK signaling, and chromatin organization, with its depletion inhibiting tumor growth in xenograft models.

DOI 10.64898/2026.10.10.758243

humanexperimental assay

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Molecular BiologyMolecular CellPeer-reviewedMar 23, 2021

Cyclin binding Cy motifs have multiple activities in the initiation of DNA replication

Manzar J. Hossain, Kuhulika Bhalla, Bruce Stillman

The paper identifies Cyclin-binding (Cy) motifs in ORC1 and CDC6 that mediate cell cycle-dependent protein interactions and regulate DNA replication initiation.

61 citations

protein sequencestatistical model

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