Markus Mayrhofer

The paper introduces Jumble, an algorithm that improves the sensitivity of detecting copy number alterations in low ctDNA samples, achieving detection limits of 1-2% for amplifications and 4-8% for deletions.

This study profiles cell-free DNA in metastatic prostate cancer patients, identifying genomic alterations, microsatellite instability, and clonal hematopoiesis as potential biomarkers.