Bram De Laere

Sensitive detection of copy number alterations in samples with low circulating tumor DNA fraction.

The paper introduces Jumble, an algorithm that improves the sensitivity of detecting copy number alterations in low ctDNA samples, achieving detection limits of 1-2% for amplifications and 4-8% for deletions.

Discovering fragment length signatures of circulating tumor DNA using Non-negative Matrix Factorization

This paper uses non-negative matrix factorization to analyze cfDNA fragment length distributions, showing it can infer tumor load, detect cancer, and identify open chromatin-associated signatures.

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

This study profiles cell-free DNA in metastatic prostate cancer patients, identifying genomic alterations, microsatellite instability, and clonal hematopoiesis as potential biomarkers.