Author

Kevin Leandro

Centro de Inovação em Biomedicina e BiotecnologiaORCID 0000-0003-3404-5138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Ana Carolina da SilvaiD· 2 shared Carina HenriquesiD· 2 shared Diana Duarte LoboiD· 2 shared Luís Pereira de AlmeidaiD· 2 shared Magda M. SantanaiD· 2 shared Miguel Monteiro LopesiD· 2 shared Rui Jorge NobreiD· 2 shared Sónia DuarteiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Ana Carolina da SilvaORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 2, 2025

rAAV-Delivered Bicistronic Artificial microRNAs for Allele-Specific Silencing Improve Motor and Molecular Outcomes in Spinocerebellar Ataxia Type 3

Ana Carolina da Silva, Carina Henriques, Diana Duarte Lobo…·Luís Pereira de Almeida

This paper develops and tests rAAV-delivered bicistronic artificial microRNAs to selectively silence mutant ATXN3 in SCA3 mouse models, showing improved motor function and reduced mutant protein aggregates.

DOI 10.1101/2025.10.02.680011

mouseexperimental assay

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Molecular BiologybioRxivPreprintMay 30, 2023

Isolation of Biologically Active Extracellular Vesicles-Associated AAVs for Gene Delivery to the Brain by Size Exclusion Chromatography

Carina Henriques, Miguel Monteiro Lopes, Patrícia Maia Correia de Albuquerque…·Rui Jorge Nobre

This paper optimizes size exclusion chromatography (SEC) for isolating biologically active EV-AAVs for non-invasive brain gene delivery, showing higher recovery and transgene expression efficiency compared to differential ultracentrifugation.

1 citation

mouseexperimental assay

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