Chao Xue

This study identifies DGKG as a key mediator of schistosomiasis-induced hepatic fibrosis through GWAS and functional validation, revealing distinct genetic architecture compared to other fibrotic diseases.

SMECT benchmarks post-GWAS methods for spatial mapping of cells associated with human complex traits, revealing trade-offs between sensitivity and specificity across methods.

This study links the developmental expression of risk genes to the age of onset of neuropsychiatric disorders, showing that disease peaks align with gene expression peaks in the prefrontal cortex.

MCGA identifies schizophrenia susceptibility genes using a multi-strategy framework integrating isoform-level eQTLs, revealing genes enriched in neuronal signaling and drug targets.

The paper constructs a cell-type-phenotype association landscape using scRNA-seq and GWAS data to identify cell-type selectivity and pleiotropy in complex diseases.

This paper introduces a framework to estimate driver tissues of complex diseases by analyzing selective gene expression from GWAS data, finding lung as a driver tissue for rheumatoid arthritis.