The Impact of Homologous Recombination Deficiency on First-line Adjuvant Chemotherapy and First-line PARPi Maintenance Therapy in Chinese Patients with Epithelial Ovarian Cancer
Lei Li, Yu Lan Gu, Mengpei Zhang, Xiaohua Shi, Zhe Li, Xinyun Xu, Tianqi Sun, Yu Jun Dong, Chao Xue, Xiaoru Zhu, Ran Lv, Kai Jiao, Xuwo Ji, Zhiyong Liang, Ying Jin, , Han Liang
This study evaluates the impact of HRD status on clinical outcomes in Chinese EOC patients undergoing first-line chemotherapy and PARPi maintenance therapy, showing improved PFS and OS in HRD-positive patients.
medRxiv · Jan 12, 2023 · PreprintGenetic & Genomic Medicine