NeurosciencebioRxivPreprint
The Norepinephrine Metabolite DOPEGAL Confers Locus Coeruleus Tau Vulnerability and Propagation via Asparagine Endopeptidase
Seong Su Kang, Xia Liu, Eun Hee Ahn…·Keqiang Ye
The paper identifies DOPEGAL as a factor that promotes Tau pathology and propagation in locus coeruleus neurons via AEP cleavage of Tau.
DOI 10.1101/688200