Author

Keqiang Ye

Chinese Academy of SciencesORCID 0000-0002-7657-8154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Anisa Azatovna GumerovaiD· 2 shared Clifford james RoseniD· 2 shared Daria LiznevaiD· 2 shared David WeinshenkeriD· 2 shared Farhath SultanaiD· 2 shared Funda KorkmaziD· 2 shared Ki Ann GoosensiD· 2 shared Liam CulleniD· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Anisa Azatovna GumerovaORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Gene-Dose-Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer's Mice

Funda Korkmaz, Steven Lee Sims, Fazilet Şen, Farhath Sultana, Victoria Laurencin, Liam Cullen, Anusha Pallapati, Avi Liu, Satish V. Rojekar, George Penev, Ulliana Cheliadinova, Darya Vasilyeva, Guzel Burganova, Anne Macdonald, Mansi Saxena, , Mone Zaidi

This study shows that reducing Fshr expression in Alzheimer's mice improves spatial memory, with gene-dose-dependent effects, and links low FSH levels to better memory retrieval.

bioRxiv · Feb 16, 2024 · PreprintNeuroscience

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Leslie Hassanein, Bernard Mulvey, Harris E. Blankenship, Margaret Tish, Anu Korukonda, L. Cameron Liles, Amanda Lea Sharpe, Jean‐François Paré, Rosa M. Villalba, Xiangchuan Chen, Khan Hekmatyar, Jenny J. Yang, Daniel E. Huddleston, Seong Kang, Arielle Segal, , Alexa F. Iannitelli

This study shows that tyrosinase-induced neuromelanin accumulation in mouse locus coeruleus neurons causes hyperactivity, transcriptional changes, and degeneration, mimicking early stages of Alzheimer's and Parkinson's disease.

bioRxiv · Mar 7, 2023 · PreprintNeuroscience

Brain Atlas for Glycoprotein Hormone Receptors at Single-Transcript Level

Vitaly Ryu, Anisa Azatovna Gumerova, Funda Korkmaz, Seong Su Kang, Pavel Katsel, Sari Miyashita, Hasni Suhasha Kannangara, Liam Cullen, Pokman Chan, Tan‐Chun Kuo, Ashley Padilla, Farhath Sultana, Soleil A Wizman, Natan Kramskiy, Samir Zaidi, , Mone Zaidi

The paper creates a comprehensive neuroanatomical atlas of glycoprotein hormone receptor expression in the brain using single-transcript detection technologies.

eLife · Sep 2, 2022Peer-reviewedNeuroscience

The Norepinephrine Metabolite DOPEGAL Confers Locus Coeruleus Tau Vulnerability and Propagation via Asparagine Endopeptidase

Seong Su Kang, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P. Manfredsson, Xifei Yang, Hongbo Robert Luo, Larry Cameron Liles, David Weinshenker, Keqiang Ye

The paper identifies DOPEGAL as a factor that promotes Tau pathology and propagation in locus coeruleus neurons via AEP cleavage of Tau.

bioRxiv · Jul 2, 2019 · PreprintNeuroscience

Tau accumulation activates STAT1 triggering memory deficits via suppressing NMDA receptor expression

Xiao-Guang Li, Xiao-Yue Hong, Yali Wang, Shu‐Juan Zhang, Jun‐Fei Zhang, Xia‐Chun Li, Yan‐Chao Liu, Dong‐Shen Sun, Qiong Feng, Jinwang Ye, Yuan Gao, Dan Ke, Qun Wang, Hong-Lian Li, Keqiang Ye, , Jian‐Zhi Wang

This study shows that tau accumulation activates STAT1, which suppresses NMDA receptor expression, leading to memory deficits.

EMBO Reports · May 13, 2019Peer-reviewedNeuroscience