BASTA, a simple whole blood assay for measuring beta-cell antigen specific CD4+ T-cell responses in type 1 diabetes
Matthew Lacorcia, Pushpak Bhattacharjee, Abby Foster…·Stuart I. Mannering
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The University of MelbourneORCID 0000-0003-3497-3559Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Matthew Lacorcia, Pushpak Bhattacharjee, Abby Foster…·Stuart I. Mannering
Susanne H. D. Ständer, Cyril F. Reboul, Sarah N. Le…·Ashley M. Buckle
This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.
Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia…·Stuart I. Mannering
This study identifies 13 new proinsulin-derived HIPs recognized by human islet-infiltrating CD4+ T cells in T1D, highlighting proinsulin C-peptide's central role in HIP formation.