Molecular BiologybioRxivPreprint
Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains
Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara…·Eiichiro Mori
This study shows that PR poly-dipeptides from C9orf72 repeat expansion bind Kapβ2 and disrupt FUS droplet melting, contributing to nucleocytoplasmic transport deficits in ALS.
2 citations