Author

Koichiro Ishimori

Hokkaido UniversityORCID 0000-0002-5868-0462Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Eiichiro MoriiD· 3 shared Tomohide SaioiD· 3 shared Hiroyoshi MatsumuraiD· 2 shared Hiroyuki KumetaiD· 2 shared Hitoki NanauraiD· 2 shared Honoka Kawamukai· 2 shared Kazuma SugieiD· 2 shared Motonori MatsusakiiD· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Eiichiro MoriORCID

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3 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedApr 20, 2026

OptoChaperone - A biohybrid tool for regulating protein condensates in cells and in vitro

Do Thanh Tuan, Motonori Matsusaki, Honoka Ota…·Tomohide Saio

OptoChaperone enables reversible, spatiotemporal control of protein condensates using light, demonstrating efficacy in regulating disease-related condensates without chemical additives or genetic modifications.

DOI 10.1021/jacs.6c04074

proteomicsexperimental assay

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BiochemistrybioRxivPreprintJul 3, 2024

Conserved loop of a phase modifier endows protein condensates with fluidity

Honoka Kawamukai, Motonori Matsusaki, Takanari Tanimoto…·Tomohide Saio

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

DOI 10.1101/2024.07.03.601791

yeastproteomics

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Molecular BiologybioRxivPreprintOct 21, 2019

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains

Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara…·Eiichiro Mori

This study shows that PR poly-dipeptides from C9orf72 repeat expansion bind Kapβ2 and disrupt FUS droplet melting, contributing to nucleocytoplasmic transport deficits in ALS.

2 citations

humanproteomics

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