Leonardo A. Sepúlveda

Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.

Serval is a modular framework for decoding spatial transcriptomics data that introduces Cosine, a method improving transcript recovery and correlation with expression references.

The paper re-examines mRNA-protein correlations in E. coli, develops a theoretical framework accounting for cell growth and division, and validates it with simulations and data.

This paper introduces a spatial omics method that combines high spatial resolution with genome-wide profiling through optical barcoding and sequencing.