Didar Ciftci

Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.

This study uses a combined experimental platform to analyze the conformational dynamics of EAAT1, revealing that multimodal dynamics regulate its function and identifying a mutation that inhibits transport by stabilizing a paused conformation.

This paper introduces a spatial omics method that combines high spatial resolution with genome-wide profiling through optical barcoding and sequencing.