MicrobiologybioRxivPreprint
A state-structured pharmacodynamic framework separating resistance, tolerance and persistence, applied to Mycobacterium tuberculosis and Staphylococcus aureus
This paper develops a state-structured pharmacodynamic model to distinguish antibiotic resistance, tolerance, and persistence in bacteria, showing that resuscitation of dormant cells is critical for shortening treatment duration.
DOI 10.1101/2025.02.12.637810