Feng Chi Wu

This paper demonstrates that oral administration of ground transgenic tobacco seeds expressing human GAA (tobrhGAA) improves symptoms and enzyme activity in Pompe disease knockout mice.

This paper demonstrates that crotamine can deliver therapeutic genes to treat Pompe disease in vitro and in vivo, improving GAA activity and reversing clinical phenotypes.

The paper shows that polyadenylation of H3.1 mRNA displaces H3.3 from gene regulatory elements, leading to cell transformation and genomic instability.