Justin Martiniuk

Preclinical studies with ground germinated barley (GGB) for oral enzyme replacement therapy (Oral-ERT) in Pompe disease knockout mice

This paper investigates the use of ground germinated barley (GGB) as an oral enzyme replacement therapy (Oral-ERT) for Pompe disease in knockout mice, showing it can reverse enzyme defects and improve clinical phenotypes.

Preclinical studies for plant-based oral enzyme replacement therapy (Oral-ERT) in Pompe disease knockout mice with transgenic tobacco seeds expressing human GAA (tobrhGAA)

This paper demonstrates that oral administration of ground transgenic tobacco seeds expressing human GAA (tobrhGAA) improves symptoms and enzyme activity in Pompe disease knockout mice.

Crotamine as a vehicle for non-viral gene delivery for Pompe disease

This paper demonstrates that crotamine can deliver therapeutic genes to treat Pompe disease in vitro and in vivo, improving GAA activity and reversing clinical phenotypes.