Shanlong Li

This paper introduces a physics-based framework for simulating biomolecular phase separation and presents a machine learning library for metabolite-driven condensate formation.

This paper introduces a model called iConDNA to simulate DNA phase separation, capturing structural features and thermodynamic properties of DNA homopolymers and duplexes.

This paper shows antibiotic condensates activate magnesium signaling to enhance bacterial survival and drug tolerance.

HyRes simulates dynamic protein structures and interactions for IDPs, showing high accuracy across environments and generating ensembles for thousands of human IDPs.

This study investigates how phosphorylation of α-synuclein at S129 affects DNAJB1 binding to fibrils using biochemical assays and solid-state NMR.

This paper develops a coarse-grained RNA model (iConRNA) with explicit Mg2+ to simulate RNA phase separation and reveals the role of RNA folding and ion interactions in driving phase transitions.