Levi A. Garraway

The paper introduces CellMAPP and CHART to analyze multiplexed antibody imaging data, revealing modular morphological programs in response to genetic perturbations.

The paper introduces PerturbPair, a platform integrating transcriptomic and optical screens to map macrophage regulatory networks, revealing cross-modal relationships and disease-relevant gene programs.

This study uses single-cell and spatial profiling to show that inflammatory signals from macrophages and fibroblasts drive CD8 T cell exhaustion and resistance to immune checkpoint blockade in prostate cancer.

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.

The paper identifies ATM and PALB2 as CRC risk genes through germline mutation analysis and highlights homologous recombination deficiency in CRC tumors.