Ana M. Meireles

The paper introduces PerturbPair, a platform integrating transcriptomic and optical screens to map macrophage regulatory networks, revealing cross-modal relationships and disease-relevant gene programs.

This study uses dynamic caging to link live-cell behavior with transcriptional responses across perturbations, revealing new insights into immune and inflammatory gene regulation.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.

This study shows that TFEB and the Rag-Ragulator complex antagonistically regulate oligodendrocyte myelin sheath number and length in the central nervous system.

The paper uses Perturb-seq to systematically study 1,130 E3 ligases and their roles in inflammatory responses in dendritic cells, revealing co-functional modules and genetic interactions.

The paper identifies a small 142 bp enhancer in the mouse Bmp5 gene that is rapidly induced in injured tissues and responds to conserved signals.

This study shows that repression of Tfeb and Tfe3 is essential for microglia migration and function by regulating lysosomal activity in zebrafish.