Piotr Kozłowski

The paper introduces WMS, a targeted sequencing method for all human miRNA genes, identifying mutations and copy number alterations in cancer samples.

The paper analyzes somatic mutations in miRNA biogenesis genes across cancer types and identifies their impact on miRNA levels and patient survival.

The paper identifies and characterizes over 10,000 somatic mutations in miRNA genes across 10,000 cancer/normal pairs, showing some genes are overmutated in Pan-Cancer and specific cancers, and correlate with miRNA expression, staging, and survival.

This study shows increased global circRNA levels in myotonic dystrophy type 1, identifies circRNAs associated with disease severity, and links circRNA levels to muscle weakness and alternative splicing changes.

The paper analyzes somatic mutations in miRNA genes in lung cancer, identifying mutational hotspots and their potential functional consequences on miRNA function and target interactions.