Genetic & Genomic MedicineGenomics Proteomics & BioinformaticsPeer-reviewed
Boosting the power of rare variant association studies by imputation using large-scale sequencing population
Jinglan Dai, Yixin Zhang, Yuan Gao…·Sipeng Shen
This study evaluates how imputation from large-scale sequencing data improves the power of rare variant association studies, finding that TOPMed imputation increases detected variants and genes compared to whole-genome sequencing.
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