Feng Chen

This study evaluates how imputation from large-scale sequencing data improves the power of rare variant association studies, finding that TOPMed imputation increases detected variants and genes compared to whole-genome sequencing.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

The paper integrates multi-omics QTL and GWAS data to identify 123 novel biomarkers for lung cancer and reveals cross-omics regulatory pathways.

This study shows that co-stimulating Nrf2 and DKK1 in human MSCs improves their therapeutic efficacy in a mouse ACLF model by enhancing anti-inflammatory and regenerative effects.

This paper introduces a deep learning model to improve GWAS by detecting complex genetic effects, revealing potential causal pathways in disease development.