Caitriona Brennan

This paper introduces LRQ, a long-read metagenomics method that enables absolute strain abundance measurement and resolves microbial evolution in a Crohn's disease patient over eight years.

The paper analyzes gut microbiome data from three countries to show diet-microbiota associations vary by location and strain.

The paper compares ethanol and methanol extraction methods for fecal metabolomics, showing ethanol is safer for off-site collection and preserves metabolic profiles.

This paper designs and evolves synthetic syntrophic E. coli pairs using a novel algorithm, revealing metabolic changes that enhance community fitness and guide co-culture optimization.