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The paper identifies genetic regulators of 184 neuro-related proteins in human plasma and links them to disease traits and drug targets.

The paper uses whole-genome sequencing to analyze the genetic architecture of 257 cardiometabolic protein biomarkers, identifying 131 sequence variant associations and constructing polygenic scores that explain up to 45% of protein variation.

This paper calls copy number variants from whole-genome sequencing data of 6,898 individuals using a regression tree-based method, identifying 1,320 CNVs and their potential clinical impact.