Author
University of CambridgeORCID 0000-0001-8964-4571Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Peter Kreitmaier, Young‐Chan Park, Diane Swift, Arthur Gilly, Jeremy Mark Wilkinson, Eleftheria Zeggini
The paper examines DNA methylation profiles in infrapatellar fat pad and blood from osteoarthritis patients, identifies mQTLs, and uses Mendelian randomization to explore disease mechanisms.
Human Molecular Genetics · Nov 16, 2023Peer-reviewedGenetic & Genomic Medicine
Arthur Gilly, Young‐Chan Park, Grace Png, Andrei Barysenka, Iris Fischer, Thea Bjørnland, Lorraine Southam, Dániel Süveges, Sonja Neumeyer, Nigel William Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, George V. Dedoussis, Eleftheria Zeggini
The paper uses whole-genome sequencing to analyze the genetic architecture of 257 cardiometabolic protein biomarkers, identifying 131 sequence variant associations and constructing polygenic scores that explain up to 45% of protein variation.
Nature Communications · Dec 10, 2020Peer-reviewedGenetics
Grace Png, Dániel Süveges, Young‐Chan Park, Klaudia Walter, Kousik Kundu, Ιωάννα Ντάλλα, Emmanouil Tsafantakis, Maria Karaleftheri, George V. Dedoussis, Eleftheria Zeggini, Arthur Gilly
This paper calls copy number variants from whole-genome sequencing data of 6,898 individuals using a regression tree-based method, identifying 1,320 CNVs and their potential clinical impact.
Genetic Epidemiology · Sep 14, 2019Peer-reviewedBioinformatics
Jie Zheng, Winfried Maerz, Ingrid Gergei, Marcus Edi Kleber, Christiane Drechsler, Christoph Wanner, Vincent Mathias Brandenburg, Sjur Reppe, Kaare Morten Gautvik, Carolina Medina‐Gómez, Enisa Shevroja, Arthur Gilly, Young‐Chan Park, George V. Dedoussis, Eleftheria Zeggini, , Jonathan H. Tobias
This paper uses Mendelian Randomization to show that higher circulating sclerostin levels causally reduce bone mineral density and increase fracture risk.
Journal of Bone and Mineral Research · Jun 6, 2019Peer-reviewedGenetics